Research Network for Metals in Medicine

 

 

Dr Louis M Rendina

BSc(Hons), PhD(ANU)

Position: Senior lecturer in Chemistry

Affiliation: School of Chemistry, University Sydney

Postal Address:
School of Chemistry, Building F11
University of Sydney, NSW, 2006
AUSTRALIA

Phone: +61 (2) 9351 4781
Fax: +61 (2) 9351 3329
Email: rendina@chem.usyd.edu.au
Webpage: http://www.chem.usyd.edu.au/about/staff_rendina.html


Research Profile

LMR received his B.Sc. with First-Class Honours in Chemistry from the Australian National University (ANU) in 1988. From 1988-1991 he was the recipient of a Commonwealth Postgraduate Research Award, and he obtained his Ph.D. in Bio-inorganic Chemistry (under the supervision of J. A. Broomhead) in 1991. He was then awarded an ANU-IAS Postdoctoral Fellowship to work with Prof. M. A. Bennett, FRS, at the Research School of Chemistry, Institute of Advanced Studies, ANU. In 1993 he was awarded a prestigious NSERC Canada International Fellowship to work with Prof. R. J. Puddephatt, FRS, at the University of Western Ontario, Canada. In late 1995 he returned to the Australian National University as a Visiting Fellow, and in 1996 he was appointed as Lecturer in Chemistry at the University of Adelaide. He was promoted to the position of Senior Lecturer in 2000, and he moved to the School of Chemistry at the University of Sydney in 2003.
LMR is a young scientist who has made several important contributions to the fields of synthetic organometallic and coordination chemistry. Over the past few years, his research group has embarked upon the synthesis and DNA-binding properties of carborane-containing metal complexes, culminating in the recent discovery of two new classes of DNA-binding agents for potential use in Boron Neutron Capture Therapy (BNCT). In 2002, an international patent application (Patent Cooperation Treaty Application No. PCT/AU02/00943) entitled “Metal Complexes for use in Boron Neutron Capture Therapy” was filed by LMR under the auspices of The University of Adelaide’s commercial arm, Adelaide Research and Innovation, Pty Ltd. LMR’s group has also been involved in the construction of large inorganic macrocycles by non-covalent means, including the first characterised examples of multimeric, H-bonded macrocycles of platinum with nanoscale dimensions.


Selected Publications

  1. Todd, J. A.; Rendina, L. M. “The First Examples of Platinum(II)-Amine Complexes Containing 1,2-Dicarba-closo-dodecaborane(12)”, Inorg. Chem. Commun., in press.
  2. Crisp, M. G.; Tiekink, E. R. T.; Rendina, L. M. “cationic sPhenylplatinum(II) Complexes with Carboxylic Acid Functionality: pKa Determinations and X-ray Structures”, Inorg. Chem., 2003, 42, 1057 – 1063.
  3. Todd, J. A.; Rendina, L. M. “Synthesis and DNA-Binding Properties of Cationic 2,2’:6’,2”-Terpyridineplatinum(II) Complexes Containing 1,2- and 1,7-Dicarba-closo-dodecaborane(12)”, Inorg. Chem., 2002, 41, 3331 – 3333.
  4. Woodhouse, S. L.; Rendina, L. M. “Synthesis and DNA-Binding Properties of Dinuclear Platinum(II)-Amine Complexes of 1,7-Dicarba-closo-dodecaborane(12)”, Chem. Commun., 2001, 2464 – 2465.
  5. Gallasch, D. P.; Tiekink, E. R. T.; Rendina, L. M. “A New Methodology for the Preparation of Cationic Organoplatinum(II) Complexes with Hydrogen-Bonding Functionality”, Organometallics, 2001, 20, 3373 – 3382.
  6. Gianneschi, N. C.; Tiekink, E. R. T.; Rendina, L. M. “Dinuclear Platinum Complexes with Hydrogen Bonding Functionality: Noncovalent Assembly of Nanoscale Cyclic Arrays”, J. Am. Chem. Soc., 2000, 122, 8474 – 8479.


Facilities

  • Bio-Rad DNA electrophoresis equipment
  • CCD camera


International Linkages

A/Prof. J. A. Coderre (Department of Nuclear Engineering, Massachusetts Institute of Technology, USA)