Research Network for Metals in Medicine

 

 

Professor Thomas Maschemeyer

BSc(Hons), PhD(Syd)

Position: Professor, Chemistry

Affiliation: University of Sydney, School of Chemistry

Postal Address:
Centre for Molecular Catalysis
School of Chemistry - F11
The University of Sydney
NSW 2006
AUSTRALIA

Phone: +61 (02) 9351 2581
Email: th.maschmeyer@chem.usyd.edu.au
Webpage: www.chem.usyd.edu.au/about/staff_maschmeyer.html


Research Profile

Professor Thomas Maschmeyer (born 1966, Hamburg) received his BSc (Hons I) (1991) and PhD (1995) from the University of Sydney. In 1994 he went as Australian Bicentennial Fellow to the Royal Institution (R.I.), London, to work with Professor Sir John Meurig Thomas. Subsequent positions include the Assistant Directorship of the Davy Faraday Laboratories, R.I. (1995–1998), and an Associate Lecturership at the University of Cambridge in combination with an affiliate Fellowship at Peterhouse (1996–1998). In 1998 Professor Maschmeyer succeeded Professor Herman van Bekkum as Chair of Industrial Organic Chemistry at the Delft University of Technology (T.U.D.), where he also became Vice-Chairman of the Delft Institute of Chemical Technology in 2000. In late 2003 he commenced his new position as Federation Fellow in connection with a Personal Chair as Professor of Chemistry at the University of Sydney.

His current interests lie in the areas of Catalysis, Renewable Feedstocks (Hydrogen, Biomass), Sustainable Processes (‘Green’ Chemistry), High Throughput Experimentation (Robots, Automation), Micro- and Mesoporous Nano-sized Materials, Computational Chemistry and Enantioselective Reactions

The underlying principle of Professor Maschmeyer’s work is that only via a solid molecular understanding, real progress in the development of new concepts and, subsequently, applications can be achieved.

The research activities pursued by him and the various teams he worked with have led, on the fundamental side, to novel, deep insights into hitherto unexplained chemical phenomena strongly controlling catalyst performance (selectivity, activity and life time), to the development of many syntheses of nanostructured materials as well as instrumental techniques to study catalysts under reaction conditions (high pressures, temperatures, on-line analysis, etc.). On the applied side, the research has led to a number of significant commercial process improvements as well as the start-up of two spin-off companies (the largest being ‘Avantium’ with, in 2001, 100+ workers).

In the area of ‘Metals in Medicine’, he has been involved in the design and synthesis of molecular targeting agents with the aim to develop specificity towards certain cancer cells as well as the development of more efficient MRI contrast agents (relevant publications below)


Selected Publications

  1. W. Ma, H. van Koningsveld, J.A. Peters and Th. Maschmeyer, Zirconium (IV) complexes of oxydiacetic acid in aqueous solution and in the solid state as studied by multinuclear NMR and X-ray crystallography, Chem. Eur. J. 7(3), 2001, pp. 657-663
  2. J. Rohovec, J. Kotek, J.A. Peters, Th. Maschmeyer, A Clean Conversion of D-Glucosamine Hydrochloride to a Pyrazine Derivative in the presence of Phenylboronate or Borate, Eur. J. Org. Chem. 2001, pp. 3899-3901
  3. C. Platas-Iglesias, L. Vander Elst, W. Zhou, R.N. Muller, C.F.C.G. Geraldes, Th. Maschmeyer, J.A. Peters, Zeolite GdNaY Nanoparticles with Very High Relaxivity for Applications as Contrast Agents in Magnetic Resonance Imaging, Chem. Eur. J. 8(22), 2002, pp. 5121-5131
  4. C. Platas-Iglesias, D.M. Corsi, L. Vander Elst, R.N. Muller, D. Imbert, J.-C.G. Bünzli, E. Toth, Th. Maschmeyer, J.A. Peters, Stability, structure and dynamics of cationic lanthanide(III) complexes of N,N’-bis(propylamide)ethylenediamine-N,N’-diacetic acid, Dalton Trans., 2003, pp. 727-737
  5. J. Rohovec, Th. Maschmeyer, S. Aime, J.A. Peters, The structure of the Sugar Residue in Glycated Human Serum Albumin and Its Molecular Recognition by Phenylboronate, Chem. Eur. J. 9, 2003, pp, 2193-2199
  6. Kotek, Jan; Lebduskova, Petra; Hermann, Petr; Vander Elst, Luce; Muller, Robert N.; Geraldes, Carlos F. G. C.; Maschmeyer, Thomas; Lukes, Ivan; Peters, Joop A (2003). "Lanthanide(III) complexes of novel mixed carboxylic-phosphorus acid derivatives of diethylenetriamine: A step towards more efficient MRI contrast agents." Chemistry--A European Journal 9(23): 5899-5915.


Facilities

In addition to School of Chemistry, S.U. general facilities: Robotic high speed synthesis and screening equipment, linkages to former group: specialised NMR/MRI equipment.


International Linkages

My academic collaborations are with Professors:
J.A. Peters, Delft, The Netherlands, Targeted MRI contrast agents and anti-cancer drugs
J.M. Thomas, Cambridge, UK; Catalysis of Bimetallic Nanoparticles
C.R.A.C. Catlow, Royal Institution, London, UK; Computational approaches to Catalyst design
D. Bruce, Exeter, UK; St. Andrews, UK; One-step synthesis of supported catalysts
L. Marchese, S. Colluccia, Turin, Italy; Spectroscopic invetsigations of catalytic materials