Research Network for Metals in Medicine

 

 

Professor Leonard F Lindoy

BSc(Hons)(UNSW), PhD(UNSW), DSc(UNSW), FAA

Position: Professor of Inorganic Chemistry

Affiliation: School of Chemistry, University of Sydney

Postal Address:
School of Chemistry, Building F11
University of Sydney, NSW, 2006
AUSTRALIA

Phone: +61 (2) 9351 4400
Fax: +61 (2) 9351 3329
Email: L.Lindoy@chem.usyd.edu.au
Webpage: http://www.chem.usyd.edu.au/~lindoy


Research Profile

Professor Lindoy has received the following major awards/honours reflecting contributions to metal coordination/supramolecular chemistry:

2004 Appointed to the IUPAC Committee, Division (VIII) of Chemical Nomenclature and Structure.

2003 Awarded a Centenary Medal by the Australian Government for contributions to Inorganic Chemistry.

2002 Royal Society of Chemistry (UK) lecturer for Australia and New Zealand

2001 Awarded the RACI Olle Prize for chemical literature (with I. M. Atkinson, JCU) for a monograph published by the Roy. Soc. Chem. (UK) in supermolecular/supramolecular chemistry .

2000 Royal Society of Chemistry (UK) Lecturer for Australia and New Zealand.

1998 Liversidge Research Lecturer of the Royal Society of New South Wales

1995 H. G. Smith Medal This is the senior research award of the RACI.

1995 Awarded the AINSE Gold Medal for Excellence in Research.

1993 Elected a Fellow of the Australian Academy of Science.

1991 Awarded the RACI National (Burrows) Award for Inorganic Chemistry.

1988 Awarded the RACI Olle Prize for chemical literature.

Professor Lindoy is author or co-author of approximately 225 research publications and holds four patents. He is a member of, or has served terms on, five international journal editorial boards. He has held ARGS/ARC/Discovery Large Grant funding without interruption since 1973. Past positions include: Chair of the Australian Journal of Chemistry Editorial Advisory Board; Chair of both the ARC Chemistry Large Grants Sub panel and the ARC Physical Sciences Panel; President of AINSE. The CI's research standing has been recognised by frequent invitations to present plenary and major conference lectures at national and international conferences (approx. 2-4 per year over the past 15 years). More recent invited lectures include: 31 ICCC Vancouver, 1996, Plenary; XXII ISMC Seoul, 1997, Plenary; Liversidge Research Lecture for 1998, Roy. Soc. NSW; Intern. Conf. on Supramolecular Science, Zakopane (Poland), 1998, Plenary; RACI Inorg. Div. Conf., Wollongong, 1998, Plenary; 34 ICCC Edinburgh, 2000, Conference Lecture; 26th ISMC, Conference Lecture, Fukuoka, Japan, 2001; 'E.Kimura Symposium', Hiroshima, Japan, 2001, Conference Lecture; Singapore Internat. Chem. Conf., Singapore, 2001, Conference Lecture; Third International Conference on Supramolecular Science & Technology, Buenos Aires, 2002, Conference Lecture; 36th Convention of the South African Chemical Institute, Port Elizabeth, Plenary Lecture; Iranian Chemical Society Conference, Zanjan, Plenary Lecture, 2003; RSC Coordination Chemistry Discussion Group, Manchester, Keynote Lecture, 2003; 28th ISMC, Gdansk, 2003, Conference Lecture.

Professor Lindoy has made important contributions, some of them seminal, to the areas of macrocyclic and supramolecular chemistry as well as to the development of new radio pharmaceuticals based on 99Mo and 64Cu. Individual studies cross all three areas and, indeed, the interconnectivity of much of the research achieved has been a feature of the output from his group. Professor Lindoy has been responsible for the design, synthesis and characterisation of a very large number of new ligand systems over many years. The capability of specifically designing and synthesising new macrocyclic ring and cage systems for use in host-guest chemistry has served to underwrite many subsequent studies. In particular, a major contribution has been made in the area of the design and synthesis of new receptor systems for metal-ion (with emphasis on heavy metals) and small molecule recognition. Around 75 publications have appeared under this theme. This work has led to new concepts ('dislocation discrimination', 'selective detuning') and has been applied to the related areas of membrane transport, solvent extraction as well as to reagent design for radioimaging and therapy.


Selected Publications

  1. Metal ion recognition. The interaction of selected transition and post-transition metal ions with a mono-N-benzylated O2N3-donor macrocycle and its xylyl-bridged ring analogue, M. Fainerman-Melnikova, A. Nezhadali, G. Rounaghi, J. C. McMurtrie, J. Kim, K. Gloe, M. Langer, S. S. Lee, L. F. Lindoy, T. Nishimura, K.-M. Park and J. Seo, Dalton Trans., 2004, 122-128.
  2. Metal-ion Recognition. Selective Bulk Membrane Transport of Silver(I) Using Thioether Donor Macrocycles as Ionophores and X-ray Structure of the Silver Complex of a S4-Donor Ring, Marina Fainerman-Melnikova, L. F. Lindoy, S.-Y. Liou, J. C. McMurtrie, N. P. Green, A. Nezhadali, G. Rounaghi and W. N. Setzer, Aust. J. Chem., 2004, in press.
  3. 1,3,5-Tris(4-formylphenoxmethyl)-2,4,6-trimethylbenzene ethyl acetate solvate, D. J. Bray, L. F. Lindoy and J. C. McMurtrie, Acta. Cryst. (E), 2004, 60, o6-o8.
  4. Inherent helicity in an extended tris-bipyridyl molecular cage, D. F. Perkins, L. F. Lindoy, G. V. Meehan, P. Turner, Chem. Commun., 2003, in press.
  5. 1,3,5-Tris(phenoxymethyl)-2,4,6-trimethylbenzene, D. Bray, L. F. Lindoy, J. C. McMurtrie, Acta Cryst.(E), 2003, 59, o1544-o1545.
  6. Host-guest assembly of ligand systems for metal ion complexation; synergistic solvent extraction of copper(II) ions by N3O2-donor macrocycles and carboxylic or phosphinic acids; K. A. Byriel, V. Gasperov, K. Gloe, C. H. L. Kennard, A. J. Leong, L. F. Lindoy, M. S. Mahinay, H. T. Pham, P. A. Tasker, D. Thorp and P. Turner; Dalton Trans., 2003, 3034-3040.
  7. New Macrocyclic Ligands. XVI Synthesis of a Series of N-Benzylated Macrocycles Incorporating N4O2-Donor Sets; R. R. Fenton, L. F. Lindoy, J. R. Price, B. W. Skelton and A. H. White; Aust. J. Chem., 2003, 56, 1141-1145.
  8. Metal Ion Recognition. Interaction of a series of successively N-benzylated derivatives of 1,4,8,11-tetraazacyclotetradecane (cyclam) with selected transition and post-transition metal ions. Y. Dong, S. Farquhar, K. Gloe, L. F. Lindoy, B. R. Rumbel, P. Turner and K. Wichmann; Dalton Trans., 2003, 1558-1566.
  9. A Comparative Study of Supramolecular Assemblies Containing N''-(5,6-dimethyl-1H-benzimidazol-2-yl)guanidine, 2-guanidinobenzimidazole and their Ni(II) complexes. M. M. Bishop, A. H. W. Lee, L. F. Lindoy, P. Turner, Polyhedron, 2003, 735 - 743. (Invited paper, special metallosupramolecular chemistry volume).
  10. Macrocyclic ligand design. Interaction of a series of successively N-benzylated derivatives of 1,4,8,11-tetraazacyclotetradecane (cyclam) with copper(II) and nickel(II). Y. Dong, G. A. Lawrance, L. F. Lindoy and P. Turner, J. Chem. Soc., Dalton Trans., 2003, 1558-1575.
  11. Synthesis of Novel Multi-Ligands Tetraazamacrocycles for Radiolabelling Proteins with 64Cu for Therapy, M. Ramli, L. F. Lindoy, S. V. Smith and Y. Dong, J. Label Compd. Radiopharm., 2003, 46, S358.
  12. (1,4,7,11,14,17-hexathia-9,9,19-19-tetrahydroxymethylcycloicosane)silver(I) nitrate. M. Fainerman-Melnikova, L. F. Lindoy, J. C. McMurtrie and W. N. Setzer, Acta Cryst.(E), 2003, 59, m880-m882.
  13. Self-Assembly Directed By NH-O Hydrogen Bonding. K. A. Jolliffe and L. F. Lindoy, Encyclopedia of Nanoscience and Nanotechnology, Marcel Dekker, Eds. J. A. Schwarz, C. Contescu and K. Putyera, 2003, in press.
  14. Manganese: Chapter 4. D. C. Weatherburn, S. Mandal, S. Mukhopadhyay, S. Bhaduri and L. F. Lindoy, in Comprehensive Coordination Chemistry II, Elsevier, Eds. J. A. McCleverty and T. J. Meyer, 2003.
  15. A three-ring, linked cyclam derivative and its interaction with selected transition and post-transition metal ions. Coord. Chem. Rev., Y. Dong and L. F. Lindoy, 2003, 245, 11-16.
  16. Molecular Modeling And Related Computational Techniques. M. Grotjahn, K. Gloe and L. F. Lindoy, in the Encyclopedia of Supramolecular Chemistry, J. Atwood and J. Steed Eds., Marcel Dekker, New York, 2003, in press.
  17. Solvent extraction of metal sulfates by zwitterionic forms of ditopic ligands. H. Miller, S. Parsons, A. Parkin, P. A. Tasker, L. F. Lindoy and D. J. White, J. Chem. Soc., Dalton Trans., 2003, 55-64.
  18. A Comparative Investigation of Supramolecular Structures Involving Copper(II) Complexes of Imidazolinylalkanimidamides. Michael M. Bishop, Leonard F. Lindoy, Daniel J. Miller and Peter Turner, J. Chem. Soc., Dalton Trans., 2002, 4128-4133.
  19. A proton induced conformational change in metal complexes with potential hydrogen bonding triplet motifs, I. M. Atkinson, M. M. Bishop, L. F. Lindoy, S. Mahadev and P. Turner, Chem. Comm., 2002, 2818-2819.
  20. New Macrocyclic Ligands. XV. Isomeric, benzylated and xylyl-linked macrocyclic ligands derived from selectively protected N3O2-donor rings, K. J. Park, J.-H. Kim, G. V. Meehan, T. Nishimura, L. F. Lindoy, S. S. Lee, K.-M. Park, and I.Yoon, Aust. J. Chem., 2002, 55, 773-778.
  21. Ligand assembly and metal ion complexation. Synthesis and X-ray structures of Ni(II) and Cu(II) benzoate and 4-tert-butylbenzoate complexes of cyclam, L. F. Lindoy, M. S. Mahinay, B. W. Skelton and A. H. White, J. Coord. Chem., 2002, (JDA498) accepted. (Invited paper, special Macrocyclic Chemistry volume).
  22. Metal ion recognition. The interaction of cobalt(II), nickel(II), copper(II), zinc(II), cadmium(II), silver(I) and lead(I) with N-benzylated macrocycles incorporating O2N2-, O3N2- and O2N3-donor sets, J. Kim, T.-H. Ahn, M. Lee, A. J. Leong, L. F. Lindoy, B. R. Rumbel, B. W. Skelton, T. Strixner, G. Wei and A. H. White, J. Chem. Soc., Dalton Trans., 2002, 3993-98.
  23. A second generation dendrimer incorporating nine S2N2-donor macrocycles and its palladium(II) complex; I. M. Atkinson, J. D. Chartres, A. M. Groth, L. F. Lindoy, M. P. Lowe and G. V. Meehan, Chem. Commun., 2002, 2428-29.
  24. Metal-Ion Recognition. Modeling the stability constants of some mixed-donor macrocyclic metal ion complexes - a simple model, K. R. Adam, D. S. Baldwin, L. F. Lindoy, G. V. Meehan, I. Vasilescu and G. Wei, Inorg. Chim. Acta, 2003, 352, 46-50. (Invited paper, Martin A. Bennett commemorative volume).
  25. New Macrocyclic Ligands. XIV. Synthesis and X-ray Structures of potentially pentadentate ligands incorporating non-symmetrically arranged N4S-, N3OS-, N2O2S- and N2S2O-heteroatoms, D. S. Baldwin, B. F. Bowden, P. A. Duckworth, L. F. Lindoy, B. McCool, G. V. Meehan, I. Vasilescu and S. B. Wild, Aust. J. Chem., 2002, 597-603.
  26. Macrocyclic ligand design. Structure-function relationships involving the interaction of pyridinyl-containing, mixed oxygen-nitrogen donor macrocycles with cobalt(II), nickel(II), copper(II), zinc(II), cadmium(II), silver(I) and lead(II). R. R. Fenton, R. Gauci, P. C. Junk, L. F. Lindoy, R. C. Luckay, G. V. Meehan, J. R. Price, P. Turner and G. Wei, J. Chem. Soc., Dalton Trans., 2002, 2185-93. (The RSC advised that the web-version of this paper was the most accessed (526 times) for May, 2002.)
  27. Competitive bulk membrane transport and solvent extraction of transition and post transition metal ions using mixed-donor acyclic ligands as ionophores. S. S. Lee, I. Yoon, K. M. Park, J. H. Jung, L. F. Lindoy, A. Nezhadali, G. Rounaghi. J. Chem. Soc., Dalton Trans., 2002, 2180-84.
  28. Self-assembly directed by NH-O hydrogen bonding: New layered molecular arrays derived from 4-tert-butylbenzoic acid and aliphatic diamines; R. S. Armstrong, I. M. Atkinson, E. Carter, M. S. Mahinay, B. W. Skelton, P. Turner, G. Wei, A. H. White and L. F. Lindoy, Proc. Nat. Acad. Sci., 2002, 99, 4987-4992.
  29. Metal ion recognition. Selective interaction of Silver(I) with tri-linked N2S2-donor macrocycles and their single-ring analogues, J. D. Chartres, A. M. Groth, L. F. Lindoy, and G. V. Meehan, J. Chem. Soc., Dalton Trans., 2002, 371-376.
  30. Supramolecular assembly: a comparative structural study of the incorporation of bis(2-guanidinobenzimidazolo)nickel(II) into supramolecular arrays; M. M. Bishop, L. F. Lindoy and P. Turner, Supramolecular Chem., 2002, 14, 179-188. .(Invited paper, E.Kimura retirement issue.)
  31. Compartmental Schiff-base Ligands as Selective Double-loaded Extractants for Copper(II). D. Black, R. L. Finn, L. F. Lindoy, A. Nezhadali, G. Rounaghi, P. A. Tasker and M. Schröder, Chem. Commun., 2002, 340-341.
  32. Modification of supramolecular motifs: some effects of incorporation of metal complexes into supramolecular arrays. M. M. Bishop, L. F. Lindoy, B. W. Skelton and A. H. White, J. Chem. Soc., Dalton Trans., 2002, 377-382.
  33. Synergistic solvent extraction of Co(II), Ni(II), Cu(II) and Zn(II) based on supramolecular assemblies, V. Gasperov, K. Gloe, A. J. Leong, L. F. Lindoy, M. S. Mahinay, H. Stephan, P. A. Tasker and K. Wichmann, Proc. Intern. Solv. Extract. Conf. (ISEC 2002), 2002, 353-359. (ISBN 1-919-783-25-3).
  34. Self-Assembly Directed by NH-O Hydrogen Bonding: New Molecular Assemblies Derived from N,N-Tetramethyl-1,2-Diaminoethane and Malonic or Fumaric Acid Incorporating 'Proton Transfered' Hydrogen Bonds, K. R. Adam, I. M. Atkinson, L. F. Lindoy, B. J. McCool and T. Rambusch, J. Supramol. Chem., 2001 (published 2003) 1, 201-205. (Invited paper in issue to mark the 60thBirthday of J. L. Atwood.)
  35. A Supramolecular Assembly Containing an Unusually Short N-H…N Hydrogen Bond - An X-ray and Neutron Diffraction Study. M. M. Bishop, L. F. Lindoy, O. T. Thorn-Seshold, R. O. Piltz and P. Turner, Heterocyclic Chem., 2001, 38, 1377-1382. (Invited paper in Honour of J. S. Bradshaw's retirement).
  36. Metal Ion Recognition. Interaction of New Oxygen-Nitrogen Donor Macrocycles with Selected Transition and Post-Transition Metal Ions; Effendy, R. R. Fenton, L. F. Lindoy, B. W. Skelton, J. R. Price, T. Strixner, G. Wei and A. H. White; J. Incl. Phen. Macrocyc. Chem., 2001, 41,185-191. (Invited paper associated with 26th ISMC, Fukuoka.)
  37. New Macrocyclic Ligands. XIII. Single-ring and Tri-linked Macrocyclic Systems Derived from Selectively Protected Cyclam, Y. Dong and L. F. Lindoy, Aust. J. Chem., 2001, 291-298.
  38. New linked macrocyclic systems. Interaction of palladium(II) and platinum(II) with tri-linked N2S2-donor macrocycles and their single-ring analogues. I. M. Atkinson, J. D. Chartres, A. M. Groth, L. F. Lindoy, M. P. Lowe, G. V. Meehan, B. W. Skelton, and A. H. White, J. Chem. Soc., Dalton Trans., 2001, 2801-2806.
  39. Macrocyclic ligand design. A synthetic, solvent extraction, computational and NMR study of the effect of cryptand flexibility on sodium ion affinity, K. R. Adam, I. M. Atkinson, J. Kim, L. F. Lindoy, O. A. Matthews, G. V. Meehan, F. Raciti, B. W. Skelton, N. Svenstrup and A. H. White, J. Chem. Soc., Dalton Trans., 2001, 2388-2397.
  40. New macrocyclic ligands. XII Phosphonic and phosphinic acid pendant arm derivatives of mixed donor macrocycles: towards new selective reagents for lead(II), R. F. Fenton, L. F. Lindoy, R. C. Luckay, F. R. Turville and G. Wei, Aust. J. Chem., 2001, 54, 59-62.
  41. The effect of alkylation of N- and O-donor atoms on their strength of coordination to silver(I), A. N. Widmer-Cooper, L. F. Lindoy and J. R. Reimers, J. Phys. Chem., 2001, 105, 6567-6574.
  42. Comparative DFT and X-ray structural studies of five co-ordinate, N4-donor macrocyclic ligand complexes of Cu(II) and Zn(II). L. F. Lindoy, T. Rambusch, B. W. Skelton and A. H. White, J. Chem. Soc., Dalton Trans., 2001, 1857-1861. (The RSC advised that this paper was amongst the top 10% of web-cited papers for this issue.)
  43. Macrocyclic ligand design. X-ray, DFT and solution studies of the effect of N-methylation and N-benzylation of 1,10-diaza-18-crown-6 on its affinity for selected transition and post-transition metal ions. T. W. Hambley, L. F. Lindoy, J. R. Reimers, P. Turner, G. Wei and A. N. Widmer-Cooper, J. Chem. Soc., Dalton Trans., 2001, 614-620.
  44. Formation of folded pseudo-macrocyclic complexes in the extraction of nickel(II) by phenolic oxime and aliphatic diamine ligands. V. M. Hultgren, I. M. Atkinson, R. L. Beddoes, D. Collison, C. D. Garner, M. Helliwell, L. F. Lindoy and P. A. Tasker. Chem. Commun., 2001, 573-574.
  45. Proton controlled supramolecular assembly: a comparative structural study of bis(2-guanidinobenzimidazolo)nickel(II) with bis(2-guanidinobenzimidazole)nickel(II) nitrate and 2-guanidinobenzimidazole. M. M. Bishop, L. F. Lindoy, B. W. Skelton and A. White. Supramolecular Chem., 2001, 13, 293-298. (Invited paper- Paoletti issue)
  46. Transition and post-transition metal systems incorporating linked synthetic macrocycles as structural elements. J. D. Chartres, L. F. Lindoy and G. V. Meehan, Coord. Chem. Rev., 2001, 216-217, 249-286.
  47. Metallosupramolecular chemistry, L. F. Lindoy, Chem. Aust., 2001, 68, 23-25.
  48. New heteroditopic, linked macrocyclic systems derived from selectively protected N2S2-, N3O2- and N4-donor macrocycles. J. D. Chartres, A. M. Groth, L. F. Lindoy, M. P. Lowe and G. V. Meehan. J. Chem. Soc., Perkin Trans. 1., 2000, 3444-3450.
  49. New macrocyclic ligands. XI . Synthesis, X-ray structure and computational studies of a new N2O4S2-heteroatom cage. I. M. Atkinson, D. C. R. Hockless, L. F. Lindoy, O. A. Matthews, G. V. Meehan, B. W. Skelton and A. H. White, Aust. J. Chem., 2000, 799-803.
  50. Metal-ion recognition. Competitive bulk membrane transport of transition and post transition metal ions using oxygen-nitrogen donor macrocycles as ionophores. J-H. Kim, A. J. Leong, L. F. Lindoy, J. Kim, J. Nachbaur, A. Nezhadali, G. Rounaghi and G. Wei, J. Chem. Soc., Dalton Trans., 2000, 3453-3459.
  51. Self-assembly in Supramolecular Chemistry. L. F. Lindoy and I. M. Atkinson, Royal Society for Chemistry, Cambridge UK, 2000, a monograph of 224 pp.
  52. Molecular mechanics and chemical reactivity. A model study of steric effects influencing Co(III) phosphate ester hydrolysis. I. M. Atkinson and L. F. Lindoy, Coord. Chem. Rev., 2000, 200-202, 207-215.
  53. Macrocyclic ligand design. Interaction of selected transiton and post-transition metal ions with a new O2N2-donor macrocycle incorporating a methylpyridyl pendant arm. I. M. Atkinson, J. D. Chartres, G. W. Everett, X-K. Ji, L. F. Lindoy, O. A. Matthews, G. V. Meehan, B. W. Skelton, G. Wei and A. H. White, J. Chem. Soc., Dalton Trans., 2000, 1191-1198. (The RSC advised that this paper was amongst the top 10% of web-cited papers for this issue.)
  54. Modification of supramolecular motifs: perturbation of the structure of an extended hydrogen-bonded biuret array by interaction with an intercalated copper complex and methanol molecules, M. M. Bishop, L. F. Lindoy, S. Mahadev and P. Turner, J. Chem. Soc., Dalton Trans., 2000, 233-234. (The RSC advised that this paper was amongst the top 10% of web-cited papers for this issue.)
  55. New Macrocyclic Ligands. X 'Reinforced' Single-Ring and Three-Ring Systems Derived From a Common Series of O2N2- And O3N2-Macrocyclic Precursors, T.-H. Ahn, J. Kim, L. F. Lindoy and J. Wang., Aust. J. Chem., 1999, 52, 1139-1142.
  56. New Macrocyclic Ligands. IX N- Benzylated Macrocycles Incorporating O2N2-, O3N2- and O2N3-Donor Sets, J. Kim, Y. Lee, S. S. Lee, L. F. Lindoy and T. Strixner, Aust. J. Chem., 1999, 52, 1055-1059.
  57. New Macrocyclic Ligands. VIII Di- and Tri-linked Macrocyclic Ring Systems Incorporating N2O2-Donor Atoms, I. M. Atkinson, D. M. Boghai, B. Ghanbari, L. F. Lindoy, G. V. Meehan and V. Saini. Aust. J. Chem., 1999, 52, 351-358.
  58. Nuclear Magnetic Resonance Titration Studies of simple Host-guest Amine-Carboxylic Acid Systems, M. S. Mahinay and L. F. Lindoy, Kimica, 1999, 15, 1-7.

  59. Facilities

    The Lindoy group has potentiometric titration hardware and software for the quantitative determination of thermodynamic binding constants for metal-receptor interactions.


    International Linkages

    Active, long-established collaborations in the metal-binding area with the groups of Professor P. A. Tasker, Chemistry Department, University of Edinburgh, UK and Professor K. Gloe, Institute of Inorganic Chemistry, Technical University, Dresden, Germany, are in place