Research Network for Metals in Medicine

 

 

Professor Peter Lay

BSc(Hons), PhD(ANU)

Position: Professor in Chemistry

Affiliation: School of Chemistry, University of Sydney

Postal Address:
School of Chemistry, Building F11
University of Sydney, NSW, 2006
AUSTRALIA

Phone: +61 (2) 9351 4269
Fax: +61 (2) 9351 3329
Email: P.Lay@chem.usyd.edu.au
Webpage: http://www.chem.usyd.edu.au/about/staff_lay.html


Research Profile

Professor Lay has presented invited and plenary lectures at international conferences and institutions (60 since 1990 in Argentina, Denmark, France, New Zealand, Switzerland, UK, Japan and USA and national level), including: the International Conference on Biological Inorganic Chemistry, 2003; International Coordination Chemistry Conference in Endinburgh, 2000; the IUPAC World Congress of Chemistry, Brisbane, 2001 (Burrows award lecture); Metals in Medicine Gordon Conference in New Hampshire, 2002, Inorganic Reaction Mechanisms Gordon Conference in California, 2001; Asian Chemical Congress in Japan, 1997; 27th International Symposium of the ESR Group of the Royal Society of Chemistry, Cardiff, 1994; XVIIth International Conference on Organometallic Chemistry, Brisbane, July, 1996; the review of the Advanced Photon Source in Argonne (only non-American invited), 2001; and many others spanning the disciplines of chemistry and biomedical research. He has been appointed as a visiting professor at the University of Bern in 1991, a FOMEC Distinguished Professor at the University of Argentina in 1999, and a Personal Chair in Inorganic Chemistry in 1997. Professor Lay has received the Rennie Medal, Burrows Medal, and Fellowship of the Royal Australian Chemical Institute; and the Edgeworth David Medal of the Royal Society of NSW. Finally, the applicant’s research in the subject has been recognised by his appointment to the Editorial Advisory Committee of the American Chemical Society journal, Chemical Research in Toxicology in 2000 and Advances in Inorganic Chemistry in 2001. Since 1986, Professor Lay has been CI on a total of $10M in competitive grants. Finally, Professor Lay has co-supervised two Cornforth Medallists (awarded by RACI to the best chemistry PhD in Australia over the previous year). Professor Lay has published at a rate of about 10 papers per year over the last five years with 70% in major international journals of the American Chemical Society and the Chemical Society (UK) (e.g., Impact Factors: JACS 5.725; Biochemistry 4.628; J. Phys. Chem. 4.173; Chem. Res. Toxicol. 3.336; Inorg. Chem 2.97; Chem. Commun. 3.407) and the remainder in other well-respected journals or invited reviews, articles and book chapters. The applicant’s 176 career refereed publications and book chapters, have been highly cited. For the 132 papers listed in the ISI databank published before 2001, they were cited 2342 times (excluding self-citations) or an average of 17.7 per paper. If all papers up to the end of 2003 were included, there were 2398 citations (excluding self-citations) at an average of 15.6 per paper, but this is distorted by a large number of recent papers.

Professor Lay determined for the first time the Fe-ligand bond lengths and Fe N O angles of ferric nitrosyl hemeproteins using multiple-scattering analysis of X-ray absorption fine structure using fluorescence detection of the X-ray absorption spectrum from aqueous solutions. Such studies were not accessible by other techniques such as XRD and their importance lies in the understanding of the binding kinetics of NO and its varied biological roles.

Professor Lay’s group was the first to use microprobe PIXE, SRIXE, and XAS for studying the spatial distribution and intracellular biotransformation of a carcinogen and hence, is at the cutting edge of the techniques that are based on the detection of fluorescent X-rays. He has been involved in new developments in the XAFS facilities at the Australian National Beamline Facility (ANBF) in Tsukuba, Japan, including heading a recent successful ARC LIEF grant for a new 36-element pixel detector for fluorescent X-rays at the ANBF. He has honed techniques for performing XAS experiments using fluorescent X-ray detection on very reactive and air-sensitive complexes, such as Cr(IV) and Cr(V) species and has made many ground breaking contributions to understanding the bioinorganic chemistry of Cr(VI) occupational cancers that have led to three invited reviews in Comments in Inorganic Chemistry, Coordination Chemistry Reviews, Progress in Inorganic Chemistry and an invited chapter for Comprehensive Coordination Chemistry on Cr, which themselves are important contributions.

Professor Lay has made a total of nine successful visits to SSRL (international competition for beam time) to gather XAS data on heme proteins with all of the data having been analysed to produce precise information on Fe-ligand bond lengths and angles. They also have extensive experience in performing electrochemical and spectroscopic measurements on proteins, in particular, heme proteins. PALs group has used microbe PIXE at the University of Melbourne and XAS and SRIXE at Brookhaven and APS at Chicago and has made extensive use of the Australian National Beamline Facility at the Photon Factory in Japan for XAS measurements. Evidence of Professor Lay’s standing in the international community in the area of synchrotron radiation applications to bioinorganic chemistry and medicine are that he was: the only non-American to give an invited lecture at the review of the Advanced Photon Source (APS) in Chicago in 2001; he was an invited speaker and participant in the NIH-sponsored workshop to develop hard X-ray nanoprobe technologies for applications in medicine over the next five years (at the APS); he regularly receives beamtime on the highly sort after microprobe beamline at the APS; similarly he regularly obtains the full amount of time requested for XAFS at the ANBF in Tsukuba, Japan. He has also completed an invited review on multiple-scattering applications to inorganic and bioinorganic systems in a Specific Edition of Coordination Chemistry Reviews edited by Prof. Ed. Solomon. These attest to the international standing of Professor Lay’s credentials in the application of synchrotron radiation techniques to important problems in bioinorganic chemistry and medical/pharmaceutics.



Selected Publications

The following publications of the 176 career chapters and refereed articles involve research covered by this network.

    Chapters and Chapter Sections in Books and Major Critical Review Articles

  1. New Insights into the Structures and Reactions of Chromium(V) Complexes: Implications for Chromium(VI) and Chromium(V) Oxidations of Organic Substrates and the Mechanisms of Chromium Induced-Cancers. Farrell, R. P.; Lay, P. A. Comments Inorg. Chem. 1992, 13, 133-175.
  2. Studies on the Genotoxicity of Chromium: From the Test Tube to the Cell. Codd, R.; Dillon, C. T.; Levina, A.; Lay, P. A. Coord. Chem. Rev. 2001, 216-217, 537-582.
  3. Copper Complexes of Non-steroidal Anti-inflammatory Drugs: An Opportunity yet to be Realized Weder, J. E.; Dillon, C. T.; Hambley, T. W.; Kennedy, B. J.; Lay, P. A.; Biffin, J. R.; Regtop, H. L.; Davies, N. M. Coord. Chem. Rev. 2002, 232, 95-126; invited contribution for a special Biomedical issue.
  4. Chromium in Biology: Nutritional Aspects and Toxicology. Levina, A.; Codd, R.; Dillon, C. T.; Lay, P. A. Prog. Inorg. Chem. 2003, 51, 145-250.
  5. Sialoglycoprotein and Carbohydrate Complexes in Chromium Toxicity. Codd, R.; Irwin, J. A.; Lay, P. A. Curr. Opinion Chem. Biol. 2003, 7, 213-219, invited contribution.
  6. Chromium, Levina, A.; Lay, P. A. in Comprehensive Coordination Chemistry II, From Biology to Nanotechnology, McCleverty, J. A.; Meyer, T. J., Eds. Volume 4, Wedd, A. J., Vol Ed., Elsevier, Oxford, UK, 2003, Chapter 4.6, pp 313-413.
  7. Copper and Zinc Complexes as Anti-Inflammatory Drugs. Dillon, C. T.; Hambley, T. W.; Kennedy, B. J.; Lay, P. A.; Weder, J. E.; Zhou, Q. in Metal Ions in "Metal Ions and Their Complexes in Medication", Vol. 41 of 'Metal Ions in Biological Systems'; Sigel, A.; Sigel, H., Eds.; M. Dekker, Inc., New York & Basel, 2004, Ch. 8, pp 253-277.
  8. Three-Dimensional Structure Determination using Multiple-Scattering Analysis of XAFS: Applications to Metalloproteins and Coordination Chemistry. Levina, A.; Armstrong, R. S.; Lay, P.A. Coord. Chem. Rev. (Special edition on “Synchroton Radiation in Inorganic and Bioinorganic Chemistry”, Solomon, E. I., Ed.) submitted, invited contribution
  9. Mechanistic Studies of Relevance to the Biological Activities of Chromium. Levina, A.; Lay, P.A. Coord. Chem. Rev. (Special edition on “Inorganic Reaction Mechanisms”, Ford, P. C., Ed.) submitted, invited contribution
  10. Articles, Notes and Communications Published in Refereed Journals

  11. Chromium(V)-Induced Cleavage of DNA: Are Chromium(V) Complexes the Active Carcinogens in Chromium(VI)-Induced Cancers? Farrell, R. P.; Judd, R. J.; Lay, P. A.; Dixon, N. E.; Baker, R. S. U.; Bonin, A. M. Chem. Res. Toxicol. 1989, 2, 227-229.
  12. Electrochemistry of the Quasi-reversible Bis[2-ethyl-2-hydroxybutanoato(2-)]oxo-chromate(V) and (IV) and Bis[2-hydroxy-2-methylbutanoato(2-)]oxochromate-(V) and (IV) Redox Couples and the Crystal and Molecular Structure of Sodium Bis[2-ethyl-2-hydroxybutanoato(2-)]oxochromate(V) Sesquihydrate. Judd, R. J.; Hambley, T. W.; Lay, P. A. J. Chem. Soc., Dalton Trans. 1989, 2205-2210.
  13. Ligand Exchange Reactions of Chromium(V): Characterization of the Ligand Exchange Equilibria of Bis(2-ethyl-2-hydroxybutanoato(2-))oxochromate(V) in Aqueous 1,2-Ethanediol and the Solution Structure of Bis(1,2-ethanediolato(2))oxochromate(V). Bramley, R.; Ji, J.-Y.; Lay, P. A. Inorg. Chem. 1991, 30, 1557-1564.
  14. The Response of Chromium(V) to the Diphenylcarbazide Spectrophotometric Method for the Determination of Chromium(VI). Eckert, J. M.; Judd, R. J.; Lay, P. A.; Symons, A. D. Anal. Chim. Acta 1991, 255, 31-33.
  15. The Synthesis and Crystal Structure of a V(V) Complex with a 2-Hydroxyacid Ligand, (NH4)2[V(OC(CH2CH3)2COO)(O)2]2: A Structural Model of Both Vanadium(V) Transferrin and Ribonuclease Complexes with Inhibitors. Hambley, T. W.; Judd, R. J.; Lay, P. A. Inorg. Chem. 1992, 31, 343-345.
  16. Suppression by Vanadium(IV) of Chromium(V)-Mediated DNA Cleavage and Chromium(V/VI)-Induced Mutagenesis. Synthesis and Crystal Structure of the Vanadium(IV) Complex (NH4)[V(O){HOC(Et)2COO}{OC(Et)2COO}]. Barr-David, G.; Hambley, T. W.; Irwin, J. A.; Judd, R. J.; Lay, P. A.; Martin, B. D.; Bramley, R.; Dixon, N. E.; Hendry, P.; Ji., J.-Y.; Baker, R. S. U.; Bonin, A. M. Inorg. Chem. 1992, 31, 4906-4908.
  17. In Vitro DNA Damage and Mutations Induced by a Macrocyclic Tetraamide Chromium(V) Complex: Implications for the Role of Cr(V) Peptide Complexes in Chromium-Induced Cancers. Dillon, C. T.; Lay, P. A.; Bonin, A. M.; Dixon, N. E.; Collins, T. J.; Kostka, K. L. Carcinogenesis 1993, 14, 1875-1880.
  18. Synthesis, Characterization and Crystal Structure of a Vanadium(V)-(IV)-(V) Mixed-Valence Trimer with a Tridentate Quinato Ligand, (NH4)2{[Vv(O)2]2[VIV(O)](m-(-)-quinato(3-))2}.H2O. Codd, R.; Hambley, T. W.; Lay, P. A. Inorg. Chem. 1995, 34, 877-882.
  19. EPR Characterisation of the Cr(V) Intermediates in the Cr(VI/V) Oxidations of Organic Substrates and of Relevance to Cr-Induced Cancers. Barr-David, G.; Charara, M.; Codd, R.; Farrell, R. P.; Irwin, J. A.; Lay, P. A.; Bramley, R.; Brumby, S.; Ji, J.-Y.; Hanson, G. R. J. Chem. Soc., Faraday Trans. 1995, 91, 1207-1216.
  20. Investigation of the Uptake of Drugs, Carcinogens and Mutagens by Individual Mammalian Cells Using a Scanning Proton Microprobe. Cholewa, M.; Turnbull, I. F.; Legge, G. J. F.; Weigold, H.; Marcuccio, S. M.; Holan, G.; Tomlinson, E.; Wright, P. J.; Dillon, C. T.; Lay, P. A.; Bonin, A. M. Nucl. Instrum. & Meth. B 1995, B104, 317-323.
  21. Redox Potentials and Chemistry of the Chromium-(V)/(IV), (V)/(III), and -(IV)/(III) Complexes with 2-Ethyl-2-hydroxybutanoato(2-/1-) Ligands. Bose, R. N.; Fonkeng, B.; Barr-David, G.; Farrell, R. P.; Judd, R. J.; Lay, P. A.; Sangster, D. F. J. Am. Chem. Soc. 1996, 118, 7139-7144.
  22. Voltammetry of Plastocyanin at a Graphite Electrode: Effects of Structure, Charge, and Electrolyte. Niles McLeod, D. D.; Freeman, H. C.; Harvey, I.; Lay, P. A.; Bond, A. M. Inorg. Chem. 1996, 24, 7156-7157.
  23. EPR Spectroscopic Studies on the Reactions of Cr(VI) with L-Ascorbic Acid, L-Dehydroascorbic Acid and 5,6-O-Isopropylidene-L-ascorbic Acid. Implications for Chromium(VI) Genotoxicity. Zhang, L.; Lay, P. A. J. Am. Chem. Soc. 1996, 118, 12624-12637.
  24. Kinetics and Mechanism of Cr(VI) Reduction to Cr(III) by L-Cysteine in Neutral Aqueous Solution. Lay, P. A.; Levina, A. Inorg. Chem. 1996, 25, 7709-7717.
  25. Microprobe X-ray Absorption Spectroscopic Determination of the Oxidation State of Intracellular Chromium Following Exposure of V79 Chinese Hamster Lung Cells to Genotoxic Chromium Complexes. Dillon, C. T.; Lay, P. A.; Cholewa, M.; Legge, G. J.F.; Bonin, A. M.; Collins, T. J.; Kostka, K. L.; Shea-McCarthy, G. Chem. Res. Toxicol. 1997, 10, 533-535.
  26. Stability and Ligand Exchange Reactions of Chromium(IV) Carboxylato Complexes in Aqueous Solutions. Codd, R.; Lay, P. A.; Levina, A. Inorg. Chem. 1997, 36, 5440-5448.
  27. Permeability, Cytotoxicty and Genotoxicity of Chromium(V) and Chromium(VI) Complexes in V79 Chinese Hamster Lung Cells. Dillon, C. T.; Lay, P. A.; Bonin, A. M.; Cholewa, M.; Legge, G. J. F.; Collins, T. J.; Kostka, K. L. Chem. Res. Toxicol. 1998, 11, 119-129.
  28. EPR Spectroscopic Studies on the Formation of Cr(V) Peroxo Complexes in the Reaction of Cr(VI) with Hydrogen Peroxide. Zhang, L.; Lay, P. A. Inorg. Chem. 1998, 37, 1729-1733.
  29. Activation of Molecular Oxygen During the Reactions of Chromium(VI/V/IV) with Biological Reductants: Implications for Chromium-Induced Cancers. Lay, P. A.; Levina, A. J. Am. Chem. Soc. 1998, 120, 6704-6714.
  30. Determination of Iron-Ligand Bond Lengths in Horse Heart Met- and Deoxy-Myoglobin Using Multiple-Scattering Analyses of XAFS Data. Rich, A. M.; Armstrong, R. S.; Ellis, P. J.; Freeman, H. C.; Lay, P. A. Inorg. Chem. 1998, 37, 5743-5753.
  31. Determination of Fe-Ligand Bond Lengths and the Fe-N-O Bond Angle in Horse Heart Ferric and Ferrous Nitrosylmyoglobin Using Multiple-Scattering EXAFS Analyses. Rich, A. R.; Armstrong, R. S.; Ellis, P. J.; Lay, P. A. J. Am. Chem. Soc. 1998, 120, 10827-10836.
  32. Anti-Inflammatory Dinuclear Copper(II) Complexes with Indomethacin. Synthesis, Magnetism and EPR Spectroscopy; Crystal Structure of the N,N-Dimethylformamide Adduct. Weder, J. E.; Hambley, T. W.; Kennedy, B. J.; Lay, P. A.; MacLachlan, D.; Bramley, R.; Delfs, C. D.; Murray, K. S.; Moubaraki, B.; Warwick, B.; Biffin, J. R.; Regtop, H. L. Inorg. Chem. 1999, 38, 1736-1744.
  33. In Vitro Plasmid DNA Cleavage by Chromium(V) and –(IV) 2-Hydroxycarboxylato Complexes. Levina, A.; Barr-David, G.; Codd, R.; Lay, P. A.; Dixon, N. E.; Hammershøi, A.; Hendry, P. Chem. Res. Toxicol. 1999, 12, 371-381.
  34. Competition Between 1,2-Diol and 2-Hydroxy Acid Coordination in Cr(V)-quinic Acid Complexes: Implications for Stablization of Cr(V) Intermediates of Relevance to Cr(VI)-Induced Carcinogenesis. Codd, R.; Lay, P. A. J. Am. Chem. Soc. 1999, 121, 7864-7876.
  35. X-ray Absorption Spectroscopic Studies of the Chromium(IV) 2-Ethyl-2-hydroxybutanoato(1-) Complex. Levina, A.; Foran, G. J.; Lay, P. A. J. Chem. Soc., Chem. Commun. 1999, 2339-2340.
  36. Determination of Fe Ligand Bond Lengths and the Fe-N-O Bond Angles in Soybean Ferrous and Ferric Nitrosylleghemoglobin a Using Multiple Scattering XAFS Analyses. Rich, A. M.; Ellis, P. J.; Tennant, L.; Wright, P. E., Armstrong, R. S.; Lay, P. A. Biochemistry 1999, 38, 16491-16499.
  37. Determination of Iron-Ligand Bond Lengths in Ferric and Ferrous Horse Heart Cytochrome c Using Multiple-Scattering Analyses of XAFS Data. Cheng, M.-C.; Rich, A. M.; Armstrong, R. S.; Ellis P. J.; Lay, P. A. Inorg. Chem., 1999, 38, 5703-5708.
  38. Disproportionation and Nuclease Activity of Bis[2-ethyl-2-hydroxybutanoato(2-)]-oxochromate(V) in Neutral Aqueous Solutions. Levina. A.; Lay, P. A.; Dixon, N. E. Inorg. Chem. 2000, 39, 385-395.
  39. Characterization and X-Ray Absorption Spectroscopic Studies of Bis[quinato(2-)]oxochromate(V). Codd, R.; Levina, A.; Zhang, L.; Hambley, T. W.; Lay, P. A. Inorg. Chem. 2000, 39, 990-997.
  40. EPR Spectroscopic Studies of the Reactions of Cr(VI) with L-Ascorbic Acid in Buffer Solutions: Implications for Understanding the Buffer Dependences of In Vitro DNA Damage. Zhang, L.; Lay, P. A. Aust. J. Chem. 2000, 53, 7-13.
  41. EPR Studies of Chromium(V) Intermediates Generated via Reduction of Chromium(VI) by DOPA and Related Catechol(amine)s: Potential Role for Oxidized Amino Acids in Chromium-Induced Cancers. Pattison, D. I.; Lay, P. A.; Davies, M. J. Inorg. Chem. 2000, 39, 2729-2739.
  42. Reactions of Chromium(VI/V/IV) with Bis(O-ethyl-L-cysteinato-N,S)zinc(II): A Model for the Action of Carcinogenic Chromium on Zinc-Finger Proteins. Levina, A.; Bailey, A. M.; Champion, G.; Lay, P. A. J. Am. Chem. Soc. 2000, 122, 6208-6216.
  43. DNA Interactions and Bacterial Mutagenicity of Some Cr(III) Imine Complexes and Their Cr(V) Analogs. Evidence for Cr(V) Intermediates in the Genotoxicity of Cr(III). Dillon, C. T.; Lay, P. A.; Bonin, A. M.; Dixon, N. E.; Sulfab, Y. Aust. J. Chem. 2000, 53, 411-424.
  44. An Investigation into the Genotoxic Species Generated During Reduction of Chromium(VI) by Catechol(amine)s. Pattison, D. I.; Lay, P. A.; Davies, M. J. Redox Report 2000, 5, 130-132.
  45. Permeability, Cytotoxicity, and Genotoxicity of Cr(III) Complexes and Some Cr(V) Analogues in V79 Chinese Hamster Lung Cells. Dillon, C. T.; Lay, P. A.; Bonin, A. M.; Cholewa, M.; Legge, G. J. F. Chem. Res. Toxicol. 2000, 13, 742-748.
  46. Syntheses and Characterization of Anti-inflammatory Dinuclear and Mononuclear Zinc Indomethacin Complexes. Crystal Structures of [Zn2(Indomethacin)4(L)2] (L = N,N-dimethylacetamide, Pyridine, 1-Methyl-2-pyrrolidinone) and [Zn(Indomethacin)2(L1)2] (L1 = Ethanol, Methanol). Zhou, Q.; Hambley, T. W.; Kennedy, B. J.; Lay, P. A.; Turner, P.; Warwick, B.; Biffin, J. R.; Regtop, H. L. Inorg. Chem. 2000, 39, 3742-3748.
  47. EPR Spectroscopic Studies of the Reduction of Chromium(VI) Methanol in the Presence of Peptides. Formation of Long-Lived Chromium(V) Peptide Complexes. Headlam, H. A.; Lay, P. A. Inorg. Chem. 2001, 40, 78-86.
  48. An Investigation of the Chromium Oxidation State of a Monoanionic Chromium Tris(catecholate) Complex by X-ray Absorption and EPR Spectroscopies. Pattison, D. I.; Levina, A.; Davies, M. J.; Lay, P. A. Inorg. Chem. 2001, 40, 214-217.
  49. Determination of the Structures of Antiinflammatory Copper(II) Dimers of Indomethacin by Multiple-Scattering Analyses of X-ray Absorption Fine Structure Weder, J.E.; Hambley, T. W.; Kennedy, B. J.; Lay, P. A.; Foran, G. J.; Rich, A. M. Inorg. Chem. 2001, 40, 1295-1302.
  50. Chromium(VI) Reduction by Catechol(amine)s Results in DNA Cleavage In Vitro: Relevance to Chromium Genotoxicity. Pattison, D. I.; Davies, M. J.; Levina, A.; Dixon, N. E.; Lay, P. A. Chem. Res. Toxicol. 2001, 14, 500-510.
  51. Disproportionation of a Model Chromium(V) Complex Causes Extensive Chromium(III)-DNA Binding In Vitro. Levina, A.; Lay, P. A.; Dixon, N. E. Chem. Res. Toxicol. 2001, 14, 946-950.
  52. Dinuclear Chromium(V) Amino Acid Complexes from the Reduction of Chromium(VI) in the Presence of Amino Acid Ligands: XAFS Characterization of a Chromium(V) Amino Acid Complex. Headlam, H. A.; Weeks, C. L.; Turner, P.; Hambley, T. W.; Lay, P. A. Inorg. Chem. 2001, 40, 5097-5105.
  53. Preparation and Characterization of Dinuclear Copper-Indomethacin Anti-Inflammatory Drugs. Morgan, Y. R.; Turner, P.; Kennedy, B. J.; Hambley, T. W.; Lay, P. A.; Biffin, J. R.; Regtop, H. L; Warwick, B. Inorg. Chim. Acta 2001, 324, 150-161. (Invited contribution).
  54. Chromium(V)-Sialic (Neuraminic) Acid Species are Formed from Mixtures of Chromium(VI) and Saliva. Codd, R.; Lay, P. A. J. Am. Chem. Soc. 2001, 123, 11799-11800.
  55. High Resolution Nuclear and X-ray Microprobes and their Applications in Single Cell Analysis, Cholewa, M.; Dillon, C. T.; Lay, P. A.; Phillips, D.; Talarico, T.; Lai, B.; Balaic, D. X.; Barnea, Z.; Cai, Z.; Deacon, G. B.; Ilinski, P.; Legnini, P.; Rainone, S.; Shea-McCarthy, G.; Stampfl, A. P. J.; Webster, L. K.; Yun, W. Nucl. Instrum. & Meth. Phys. Res B 2001, 181, 715-722. Erratum Nucl. Instrum. & Meth. Phys. Res B 2002, 198, 108-109.
  56. Hard X-Ray Microprobe Studies of Chromium(VI)-Treated V79 Chinese Hamster Lung Cells: Intracellular Mapping of The Biotransformation Products of a Chromium Carcinogen. Dillon, C. T.; Lay, P. A.; Kennedy, B. J.; Stampfl, A. P. J.; Cai, Z.; Ilinski, P.; Rodrigues, W.; Legnini, D. G.; Lai, B.; Maser, J. J. Biol. Inorg. Chem. 2002, 7, 640-645.
  57. Redox and Ligand-Exchange Chemistry of Chromium(VI/V)–Methyl Glycoside Systems. Rizzotto, M.; Levina, A.; Santoro, M.; García, S.; Frascaroli, M. I.; Signorella, S.; Sala, L. F.; Lay, P. A. Dalton 2002, 3206-3213.
  58. Role of Tyrosine-103 in Myoglobin Peroxidase Action: Kinetic and Steady State Studies on the Reaction of Wild-Type and Mutant Recombinant Human Myoglobins with H2O2. Witting, P. K.; Mauk, A. G.; Lay, P. A. Biochemistry, 2002, 41, 11495-11503.
  59. Gastrointestinal Toxicity, Antiinflammatory Activity, and Superoxide Dismutase Activity of Copper and Zinc Complexes of the Antiinflammatory Drug Indomethacin. Dillon, C. T.; Hambley, T. W.; Kennedy, B. J.; Lay, P. A.; Zhou, Q.; Davies, N. M.; Biffin, J. R.; Regtop, H. L. Chem. Res. Toxicol., 2003, 16, 28-37.
  60. Structure and Reactivity of a Chromium(V) Glutathione Complex. Levina, A.; Zhang, L.; Lay, P. A. Inorg. Chem. 2003, 42, 767-784.
  61. Oxochromium(V) Species Formed with 2,3-Dehydro-2-deoxy-N-acetylneuraminic or N-Acetylneuraminic (Sialic) Acids: An In Vitro Model System of Oxochromium(V) Species Potentially Stabilized in the Respiratory Tract upon Inhalation of Carcinogenic Chromium(VI) Compounds. Codd, R.; Lay, P. A. Chem. Res. Toxicol. 2003, 16, 881-892.
  62. Synthesis of a Pyridinium Bis[citrato(2-)]oxochromate(V) Complex and Its Ligand-Exchange Reactions Cawich, C. M.; Ibrahim, A.; Link, K. L.; Bumgartner, A.; Patro, M. D.; Mahapatro, S. N.; Lay, P. A.; Levina, A.; Eaton, S. S.; Eaton, G. R. Inorg. Chem. 2003, 42, 6458-6468.
  63. XAFS Studies of Anti-inflammatory Dinuclear and Mononuclear Zn(II) Complexes of Indomethacin. Zhou, Q.; Hambley, T. W.; Kennedy, B. J.; Lay, P. A. Inorg. Chem. 2003, 42, 8557-8566.
  64. Solution Structures of Chromium(VI) Complexes with Glutathione and Model Thiols. Levina, A.; Lay, P. A. Inorg. Chem. 2004, 43, 324-335.
  65. X-ray Absorption Spectroscopic and Electrochemical Studies of Tris(catecholato(2-))chromate(V/IV/III) Complexes Levina, A.; Foran, G. J.; Pattison, D. I.; Lay, P. A. Agnew. Chem., Int. Ed. Engl. 2004, 43, 462-465.
  66. Effect of Metal Ions on the Electrochemistry of the Antitumour Antibiotic Streptonigrin. Anderberg, P. I.; Harding, M. M.; Lay, P. A. J. Inorg. Biochem., in press.
  67. X-Ray Absorption Spectroscopic Studies of Chromium(V/IV/III) 2-Ethyl-2-hydroxybutanoato(2-/1-) Complexes. Levina, A.; Codd, R.; Foran, G. J.; Hambley, T. W.; Maschmeyer, T.; Masters, A. F.; Lay, P. A. Inorg. Chem., in press.


Facilities

A range of facilities for the characterization of bioinorganic systems, see University of Sydney School of Chemistry web site for facilities


International Linkages

Professor Lay has collaborations with the Stanford Synchrotron Research Laboratory, the Advanced Photon Source at the Argonne National Laboratories and at the Australian National Beamline Facility in Tsukuba, Japan. He performs XAFS experiments for a range of groups throughout the world including: Professor Pat Farmer and Professor Frank Meyskens, University of California, Irvine; Professor Peter Wright, The Scripps Institute; Professor Surendra Mahapatro, Regis University, USA; Professor Dan Scherson, Case Western Reserve University; Professor Garry Roberts, University of Winconsin amongst others.