Research Network for Metals in Medicine

 

 

Dr Michael Jennings

BSc PhD (Griffith)

Position: Senior Lecturer in Molecular Microbiology

Affiliation: University of Queensland, School of Molecular and Microbial Sciences

Postal Address:
School of Molecular and Microbial Sciences
University of Queensland
Brisbane QLD 4072
AUSTRALIA

Phone: +61 (07) 3365 4879
Fax: +61 (07) 3365 4620
Email: jennings@biosci.uq.edu.au
Webpage: http://florey.biosci.uq.edu.au/mypa/academic/jennings/jennings.htm


Research Profile

The focus of research in my research group is in three main areas:

  1. Mechanisms of pathogenesis and vaccine development in human bacterial pathogens. In this area we use genetic approaches to study the mechanisms of host-pathogen interactions in pathogenic Neisseria and other respiratory pathogens such as Moraxella and Haemophilus.
  2. Vaccines development for both human and veterinary bacterial pathogens. In this area we have projects on several approaches to vaccine development in Neisseria meningitidis, the cause of meningococcal meningitis and septicaemia. We also have projects on the development of new vaccines for important bacterial pathogens in the pig and poultry industries.
  3. “Basic questions in bacterial genetics” This work focuses on the analysis of whole bacterial genomes using studies “in silico” - bioinformatics. Current projects include studies on the role of rare codons in gene expression.

Selected Publications

  1. Jennings, M.P. and Beacham, I.R. 1993. Co-dependent positive reguation of the ansB promoter of Escherichia coli by CRP and the FNR protein: A molecular analysis. Mol. Microbiol. 9:155-165.
  2. Jennings, M.P., Scott, S.P. and Beacham, I.R. 1993. Regulation of the ansB gene of Salmonella enterica. Mol. Microbiol. 9:166-173.
  3. Jennings, M.P., van der Ley, P., Wilks, K.E., Maskell, D.J., Poolman, J.T., and Moxon, E.R. 1993. Cloning and molecular analysis of the galE gene of Neisseria meningitidis and its role in lipopolysaccharide biosynthesis. Mol. Microbiol. 10:361-369.
  4. Jennings, M.P., Bisercic, M., Dunn, K.L.R., Martin, A., Wilks, K.E., Virji, M., Richards, J.C., Moxon, E.R. 1995. Cloning and molecular analysis of the lsi1 (rfaF) gene of Neisseria meningitidis which encodes a heptosyl-2-transferase involved in LPS biosynthesis: evaluation of surface exposed carbohydrates in LPS mediated toxicity for human endothelial cells. Microb. Pathogen.19:391-407.
  5. Jennings, M.P., Hood, D., Peak, I.R.A., Virji, M., and E.R. Moxon. 1995. Molecular analysis of a locus which controls the biosynthesis and phase variable expression of the lacto-N-neotetraose terminal LPS structure in Neisseria meningitidis. Mol. Microbiol. 18:724-740.
  6. Hood, D.W., Deadman, M., Jennings, M.P., Bisercic, M., Smith, H.O., Fleishman, R., Venter, C and Moxon, E.R. 1996. Use of whole genome sequence of Haemophilus influenzae to identify novel virulence genes associated with DNA repeats. PNAS 93:11121-11125.
  7. Warkarchuk, W., Martin, A., Jennings, M.P., Moxon, E.R. and Richards, J.C. 1996. Functional relationships of the gene locus encoding the glycosyltransferase enzymes involved in the expression of the lacto-N-neotetraose terminal lipopolysaccharide structure in Neisseria meningitidis. J. Biol. Chem. 271:19166-19173.