Associate Professor Margaret M Harding
BSc(Hons), PhD, FRACI
Position: Associate Professor in Chemistry, Deputy Head of School, Associate Dean (Postgraduate Research) Faculty of Science
Affiliation: School of Chemistry, University of Sydney
Phone: +61 (2) 9351 2745
Margaret Harding research has been recognised by two major awards (i) 1993 Royal Australian Chemical Institute Rennie Medal (shared) (ii) 1995 Royal Australian Chemical Institute Biota Medal for Medicinal Chemistry. Margaret Harding has 82 publications in major international journals [1999 journal impact factor in brackets: JACS (5.537), JBC (7.666), J.Med.Chem. (4.079) Biochemistry (4.493), Chem. Commun (3.477), EJB (3.307), FEBS (3.72), Inorg Chem (2.843) Dalton (2.310)]. Margaret Harding has held a Rhone-Poulenc Exchange Fellowship (Strasbourg, Lehn, 1992), an Australian Academy of Science/Royal Society Exchange Fellowship in Warwick (Rodger, CD/LD drug/DNA interactions 1998), an Australian Acadmey of Science Fellowship at the University of Houston (Haymet, antfireeze proteins, 2002) and has presented invited research lectures at major centres in Europe including the Universities of Cambridge, Oxford, Warwick, Sheffield, Birmingham (UK), Universite Louis Pasteur, Rhone-Poulenc, Lyon (France), Geneva, Basel (Switzerland), Marburg (Germany). Margaret Harding has presented lectures at the XXth International Coordination Chemistry Conference (Vancouver 1999), ICBIC (Cairns, 2003) and plenary lectures in the Metals in Medicine Symposium (9th International Conference on Coordination Chemistry of Ge, Sn, Pb), the Gordon Conference on Inorganic Chemistry in 2002 (Rhode Island,USA), Antifreeze Proteins (California 2003) and Bioorganometallic Chemistry (Zurich 2004). Margaret Harding is an Editorial Advisory Board member for Mini-Reviews in Medicinal Chemistry and Molecular Engineering-Supramolecular Science and Technology.
Margaret Harding is recognised for research at the interface of chemistry and biochemistry with key contributions to the study of drug-DNA interactions and antifreeze proteins.
Drug-DNA Interactions: The interactions of established anticancer drugs with DNA and how these interactions are related to anticancer activity have provided insight into the mechanism of action of several clincially used drugs, and provided the basis for the rational design of new drugs. Key contributions include the preparation of the first water soluble derivatives of titanocene dichloride, currently in phase II clinical trials, and molecular level studies that have established the crucial features of metal-based drugs in this class. The significance of this work has been recognised by an invitation to speak on these drugs at the Gordon Conference on Inorganic Chemistry in 2002 and at the Bioorganometallic Chemistry Sympososium in Zurich in 2004. Independent studies on the DNA-binding properties on the antitumour antibiotic streptonigrin, anthracycline antitumour antibiotics and ellipticines have contributed to the understanding of the relationship between structure, reactivity and biological activity of these drugs.
Antifreeze Proteins: The design, synthesis and structural characterisation of antifreeze proteins by Margaret Harding, combined with the computational and physical chemistry expertise of collaborators, has allowed a novel, unique and innovative approach in the field (which is dominated by biologists, not chemists), which has resulted in the synthesis of new active mutants that disproved the widely accepted mechanism for type I antifreeze proteins. The significance of the results, and the impact to researchers in the field is demonstrated by high quality publications (JACS, FEBS, EJB, JBC), and citations of these publications.
Dr Alison Rodger (University of Warwick, UK): CD and LD of drug-DNA interactions