Research Network for Metals in Medicine



Professor John DeJersey

Position: Head, School of Molecular and Microbial Sciences

Affiliation: University of Queensland

Postal Address:
Faculty of Biological and Chemical Sciences
The University of Queensland
Queensland 4072

Phone: +61 (07) 3365 4622
Fax: +61 (07) 3365 4273
Webpage: Professor John De Jersey

Research Profile

My research mostly involves studies of protein structure-function relationships and protein modification. Since proteins are involved in virtually every biological process, projects in this area can address a very wide range of biological questions. Current projects in my laboratory, many shared with academic colleagues, include studies on several groups of enzymes: the purple acid phosphatases (these contain an interesting binuclear metal catalytic centre); purine phosphoribosyltransferases (purine salvage enzymes which are potential targets for anti-malarial drugs); proteases and other proteins present in the venom of Australian snakes. I am also very interested in the covalent modification of body proteins by reactive drug metabolites, such as acetaldehyde, the major product of ingested ethanol. Our interest lies mainly in the question of how these modified proteins are involved in the pathology of alcohol abuse.These projects involve major techniques of biochemistry and molecular biology including recombinant DNA technology, bioinformatics, protein purification and structure determination.

Selected Publications

  1. Schenk, G., Boutchard, C.L., Carrington, L.E., Noble, C.J., Moubaraki, B., Murraym, K.S., de Jersey, J., Hanson, G.R. and Hamilton, S.E. (2001). A purple acid phosphotase from sweet potato contains an intiferromagnetically coupled binuclear Fe-Mn centre. J. Biol. Chem., 276, No. 22, 19084-19088.
  2. Schenk, G., Guddat, L.W., Ge, Y., dCarrington, L.E., Hume, D.A., Hamilton, S.E. and de Jersey, J. (2000). Identification of mammalian-like purple acid phosphotases in a wide range of plants. Gene, 250, 117-125.
  3. Maci, P.M., Whitaker, A.N., Sparrow, L.G., de Jersey, J., Winzor, D.J., Watters, D.J., Lavin, M.J. and Gaffney, P.J. (2000) . Textilinins from Pseudonaja textilis textilis. Characterization of two plasmin inhibitors which reduce bleeding in an animal model. Blood Coagulation and Fibrinolysis, 11, 35-393.
  4. Keough, D.T., Ng, A-L, Winzor, D.J., Emmerson, B.T., and de Jersey, J. (1999). Purification and characterization of Plasmodium falciparum hypoxanthine -guanine -xanthine phospho -ribosyl -transferase and comparison with the human enzyme. Mol. Biochem. Parasitol., 98, 29-41.
  5. Worrall, S., de Jersey, J., Wilce, P.A.., Seppa, K., Hurme, L. and Sillanuakee, P. (1998). Irreversible inactivation of purple acid phosphatase by hydrogen peroxide and ascorbate. J. Inorganic Biochemistry, 73, 245-252.