Research Network for Metals in Medicine

 

 

Dr Steve Bottle

Position: Research Program Leader, Science Research Centre, QUT

Affiliation: Queensland University of Technology

Postal Address:
School of Physical and Chemical Sciences
Queensland University of Technology
GPO Box 2434
BRISBANE QLD 4001
AUSTRALIA

Phone: +61 (07) 3864 1356
Fax: +61 (07) 3864 1804
Email: s.bottle@qut.edu.au
Webpage: http://src.sci.qut.edu.au/programs/smr/leader.jsp


Research Profile

Dr. Bottle has a strong track record in research through building and managing research teams, and has a demonstrated ability to develop and maintain successful academic collaborations and establish profitable industry contacts. Dr. Bottle serves on the Board of Directors for the Royal Australian Chemical Institute (8000 members) which is the peak body representing the profession of Chemistry in Australia. He has been awarded Fellowships from the Alexander von Humboldt Stiftung in Germany and the Australian Academy of Science as well as a Citation from the Royal Australian Chemical Institute. He has been a speaker at numerous research meetings including being a keynote lecturer at the RACI 11th National Convention in Canberra, an invited speaker the EUCHEM Free Radical conference in Rome (1998), plenary at the Southern Highlands Conference (2001) and invited speaker at the Sydney Redox Processes in Chemistry, Biology and Medicine meeting (2001). Most recently he was an invited speaker at the 2003 International Joint Meeting on Free Radicals in Health and Disease in Kyoto, Japan. He was the Jim ODonnell RACI Schools Lecturer in 2000, and served as the Queensland President of the Royal Australian Chemical Institute for 2001-2002. Dr. Bottle was recently the Deputy Director of the CIDC University Research Centre at QUT and now leads the Synthesis and Molecular Recognition Faculty Research Program (3 Academics, 2 Post-docs, 2 Research Assistants and 12 PhD students). In addition to success as 1st CI in the ARC Discovery program, Dr Bottle has successfully obtained prestigious NIH/NCI program grant funding for his research through a long standing and productive collaboration with Prof. Hal Swartz at Dartmouth Medical School, NH, USA.

Dr. Bottle has over ten years experience working on the application, design and synthesis of nitroxides and related free radical and ROS chemistry. He has been involved in the development of the technique of nitroxide radical scavenging since the very first collaborative studies between Jenkins (Griffith University) and Rizzardo (CSIRO) in the early eighties. Using this technique he was the first to investigate alkyne radical addition reactions and N-vinyl pyrrolidone electron transfer processes in radical polymerisations. He was the first person to detect methyl radical production with dimethyldioxirane; to use nitroxides and internal nitroso/nitroxides to scavenge biradicals; as well as supervise research projects which were the first to observe and simulate long lived high temperature (96K) tetraradicals; demonstrate the use of photochemically excited isoindoline nitroxides in synthesis and, most significantly, to produce a range of water soluble and other derivatives of isoindoline nitroxides. This latter synthetic work allowed the first trials of the isoindoline class of nitroxide antioxidants in biological systems and has led to promising drug leads for the disease Ataxia-Telangiectasia as well as the filing of two Patents.


Selected Publications

  1. Chen, Philip; Peng, Cheng; Luff, John; Spring, Kevin; Watters, Dianne; Bottle, Steven; Furuya, Shigeki; Lavin, Martin F. Oxidative stress is responsible for deficient survival and dendritogenesis in Purkinje neurons from ataxia-telangiectasia mutated mutant mice. Journal of Neuroscience (2003), 23(36), 11453-11460.
  2. Bottle, Steven E.; Hanson, Graeme R.; Micallef, Aaron S. Application of the new EPR spin trap 1,1,3-trimethylisoindole N-oxide (TMINO) in trapping HO.bul. and related biologically important radicals. Organic & Biomolecular Chemistry (2003), 1(14), 2585-2589.
  3. Smith, C. D.; Bottle, S. E.; Junk, P. C.; Inoue, K.; Markosyan, A. S. Synthesis and properties of Mn(hfac)2 complexes of isoindoline nitroxide radicals. Synthetic Metals (2003), 138(3), 501-506.
  4. Ishii, Kazuyuki; Bottle, Steven E.; Shimizu, Shinsuke; Smith, Craig D.; Kobayashi, Nagao. The excited multiplet states of 5,10,15-tri-n-pentyl-20-(1',1',3',3'-tetramethylisoindolin-2'-yloxyl-5'-yl)porphyrinato zinc(II). Chemical Physics Letters (2003), 370(1,2), 94-98.
  5. Shen, J.; Bottle, S.; Khan, N.; Grinberg, O.; Reid, D.; Micallef, A.; Swartz, H. Development of isoindoline nitroxides for EPR oximetry in viable systems. Applied Magnetic Resonance (2002), 22(3), 357-368.
  6. Bottle, Steven E.; Gillies, Duncan G.; Hughes, David L.; Micallef, Aaron S.; Smirnov, Alex I.; Sutcliffe, Leslie H. Synthesis, single crystal X-ray structure and W-band (95 GHz) EPR spectroscopy of a new anionic isoindoline aminoxyl: synthesis and characterization of some derivatives. Perkin 2 (2000), (7), 1285-1291.
  7. Reid, Damien A.; Bottle, Steven E.; Micallef, Aaron S. The synthesis of water soluble isoindoline nitroxides and a pronitroxide hydroxylamine hydrochloride UV-VIS probe for free radicals. Chemical Communications (Cambridge) (1998), (17), 1907-1908.


International Linkages

Professor Hal Swartz, Dartmouth Medical School Oxygen Imaging
Professor Marc Greenberg, Johns Hopkins University ROS DNA Damage
Professor Duncan Gillies, UniS, Surrey, UK. EPR High Spin Systems